Cognitive performance and memory
Attention, processing speed, memory, and executive function.
D05 · EOL evidence domain
Brain, Cognitive & Mental Resilience
Cognition, mood, sleep-linked resilience, and brain health.
Canonical subdomains
Questions within this domain.
Neurodegeneration risk and prevention
Risk factors for cognitive decline, dementia, and neurovascular aging.
Sleep architecture and quality
Sleep duration, efficiency, deep/REM sleep, insomnia-adjacent patterns.
Circadian rhythm and light exposure
Light timing, melatonin signaling, chronotype, shift work, and meal timing.
Stress resilience, HPA axis, and autonomic tone
Stress physiology, cortisol patterns, HRV, coping capacity, and recovery.
Mood and longevity / psychiatric flags
Mood, loneliness, anxiety/depression-adjacent wellbeing, and safety gates.
Meditation, mindfulness, and breathwork
Mind-body practices affecting stress, sleep, attention, HRV, and behavior.
Neuroinflammation
Inflammatory signaling related to brain aging, fatigue, mood, and cognition.
Neurovascular and metabolic brain health
Blood flow, insulin resistance, BP, lipids, and brain aging.
Nootropics and cognitive supplements
Nootropic, mushroom, herb, stimulant, and supplement claims.
Hearing, vision, and sensory aging
Sensory function as input to cognition, balance, and social connection.
Social connection and purpose
Loneliness, social ties, purpose, behavior, and mortality associations.
Fatigue and brain-body energy
Fatigue, burnout, recovery, sleep, inflammation, and metabolic contributors.
Psychedelics, ketamine, and restricted neurotherapies
Psychedelic/ketamine claims around depression, trauma, neuroplasticity, and longevity.
Digital cognitive testing
Computerized cognitive assessment, brain-age claims, and tracking tools.
Sleep tracking and wearables
Consumer sleep devices, readiness scores, HRV, and recovery metrics.