ApoB, LDL-C, and non-HDL-C
Atherogenic lipoprotein burden and lipid-marker hierarchy.
D02 · EOL evidence domain
Cardiovascular Health
Heart, blood vessels, circulation, and vascular risk.
Canonical subdomains
Questions within this domain.
Lp(a)
Genetically influenced lipoprotein risk marker.
Triglyceride-rich lipoproteins and remnants
Remnant cholesterol and TG-rich particles linked to cardiometabolic risk.
Blood pressure and vascular aging
Blood pressure patterns, arterial stiffness, sodium-potassium balance, and vascular load.
Endothelial function and nitric oxide
Vascular signaling, nitric oxide bioavailability, and endothelial health.
Atherosclerosis and CAC imaging
Subclinical plaque burden and imaging-based risk stratification.
VO2 max and cardiorespiratory fitness
Aerobic capacity, endurance training, and cardiovascular reserve.
Omega-3 index and fatty acids
Omega-3 status, EPA/DHA supplementation, and cardiovascular/inflammatory endpoints.
Electrolytes, minerals, and vascular tone
Magnesium, potassium, sodium, calcium balance, and vascular effects.
CoQ10 and myocardial energetics
CoQ10, statin-associated symptoms, and mitochondrial energy in cardiac tissue.
Inflammation and vascular risk
hs-CRP, inflammatory pathways, periodontal inflammation, and atherosclerosis.
Autonomic function, HRV, and rhythm risk
Heart-rate variability, resting heart rate, autonomic balance, and arrhythmia flags.
Thrombosis, coagulation, and enzyme claims
Nattokinase, serrapeptase, clot/plaque claims, and bleeding safety.
Sleep apnea and cardiometabolic risk
Sleep-disordered breathing as driver of BP, insulin resistance, and cardiovascular risk.
Kidney-vascular interface
Kidney function, albuminuria, BP, electrolytes, and vascular risk.
Preventive cardiovascular pharmacology
Statins, ezetimibe, PCSK9s, antihypertensives, GLP-1s, and aspirin as prevention topics.