Mitochondrial function and biogenesis
Energy production, mitochondrial density, function, and stress response.
D04 · EOL evidence domain
Cellular, Mitochondrial & Genomic Health
Cellular function, mitochondria, genetics, and biological mechanisms.
Canonical subdomains
Questions within this domain.
NAD biology
NAD metabolism, salvage pathways, aging, and cellular energy.
NMN, NR, and NAD interventions
Supplement/injection claims around NAD precursors and NAD restoration.
Cellular senescence and senolytics
Senescent-cell burden, SASP, senolytic drugs/supplements, and related claims.
Autophagy, fasting, and hormesis
Cellular recycling, nutrient sensing, fasting, heat/cold, exercise stress.
Oxidative stress and redox balance
ROS signaling, antioxidant status, redox biology, and supplement claims.
Epigenetic clocks and biological age tests
DNA methylation clocks and biological-age reporting.
Telomeres
Telomere length as aging biomarker and intervention target.
DNA repair and genomic stability
DNA damage, repair pathways, mutational burden, and aging mechanisms.
Proteostasis
Protein folding, autophagy, heat-shock proteins, and cellular cleanup.
mTOR, AMPK, and sirtuins
Nutrient-sensing pathways and aging-related signaling.
Rapamycin, metformin, and acarbose
Prescription or drug-like longevity interventions.
Peptides: SS-31, MOTS-c, and related
Mitochondrial and performance peptide claims.
Stem cells, exosomes, and regenerative claims
Regenerative biologics marketed for aging, joints, hair, skin, and repair.
Biological age testing
Testing services that estimate age-related biology from biomarkers, epigenetics, proteomics, or algorithms.
Nutraceutical polyphenols and spermidine
Food-derived compounds marketed for cellular aging mechanisms.
Heat, cold, and light hormesis
Sauna, cold exposure, red light, photobiomodulation, and adaptive stress.
Cancer flags in longevity biology
Areas where cellular aging content intersects cancer risk, growth signaling, or immune modulation.