Testosterone and androgen health
Testosterone signaling, free T, SHBG, symptoms, body composition, and aging.
D06 · EOL evidence domain
Hormonal & Endocrine Health
Hormones, endocrine systems, life stages, and regulation.
Canonical subdomains
Questions within this domain.
Menopause and estrogen/progesterone
Menopause transition, vasomotor symptoms, bone, brain, and cardiometabolic links.
Thyroid function
Thyroid hormones, TSH, symptoms, metabolism, and aging context.
Cortisol and HPA axis
Cortisol patterns, stress physiology, sleep, metabolism, and resilience.
Sex-hormone biomarker interpretation
SHBG, free T, estradiol, DHEA, LH/FSH, and context-specific interpretation fields.
Melatonin and circadian hormones
Melatonin, sleep timing, light exposure, and chronobiology.
Insulin, IGF-1, and growth signaling
Growth signaling and nutrient-sensing pathways across metabolism and longevity.
Growth hormone and secretagogues
GH, IGF-1, peptides, secretagogues, and anti-aging clinic claims.
Reproductive aging and fertility context
Age-related reproductive endocrine changes as healthspan context.
Prostate, breast, and cancer flags
Hormone-sensitive tissue risk and screening flags.
HRT/TRT protocol supervision
Hormone replacement protocols, monitoring, contraindications, and escalation rules.
Endocrine disruptors
Environmental exposures, plastics, pesticides, sleep/light, and endocrine function.
Adrenal fatigue claims
Commercial claims around adrenal fatigue and cortisol collapse.
PCOS and metabolic-endocrine bridge
Insulin resistance, androgen excess, cycles, body composition, and long-term metabolic risk.
Libido and sexual health aging
Sexual function as aging, vascular, hormonal, and psychological signal.
Functional endocrine supplements
Supplements marketed for testosterone, cortisol, thyroid, menopause, libido, and fertility.