Inflammaging and chronic low-grade inflammation
Age-related inflammatory signaling and systemic chronic inflammation.
D07 · EOL evidence domain
Immune, Inflammatory, Gut & Barrier Health
Immune balance, inflammation, gut health, and barrier function.
Canonical subdomains
Questions within this domain.
hs-CRP and inflammatory biomarkers
Objective inflammatory markers and interpretation boundaries.
Gut microbiome diversity
Microbial diversity, composition, resilience, and testing claims.
Probiotics, prebiotics, and postbiotics
Microbial products, fibers, metabolites, and strain-specific claims.
Intestinal barrier / permeability
Barrier function, zonulin claims, endotoxemia, and leaky gut marketing.
IBS and gut function
Bowel function, bloating, motility, food triggers, and quality of life.
Oral-systemic health
Periodontal health, oral microbiome, inflammation, cardiovascular/metabolic links.
Immune resilience
Immune function, infection recovery, vaccine response, and resilience framing.
Autoimmunity flags
Autoimmune disease risk flags, supplement interactions, and escalation rules.
Long COVID and chronic infection claims
Persistent symptoms, immune dysregulation, fatigue, and commercial claims.
Detox, mold, heavy metals, and parasites
Claims around mold illness, heavy metals, binders, parasite cleansing, detox protocols.
Food sensitivities and elimination diets
Food-trigger claims, elimination diets, intolerances, and immune/gut symptoms.
Mucosal immunity and barrier systems
Mucosal barriers across gut, oral, respiratory, and urogenital systems.
Immunosenescence and vaccine response
Age-related immune remodeling and vaccine-response context.
Medicinal mushrooms and beta-glucans
Mushroom products, immune claims, endurance/fatigue claims, and beta-glucan pathways.
Curcumin, boswellia, and anti-inflammatory botanicals
Botanical anti-inflammatory claims across pain, gut, joints, and systemic markers.
Histamine and mast-cell caution
Histamine intolerance, mast-cell claims, food triggers, and supplement risks.
Liver detoxification pathway translation
Phase I/II liver detox language translated into validated metabolism/safety endpoints.