Insulin sensitivity and glucose control
Regulation of glucose disposal, insulin response, and metabolic flexibility.
D01 · EOL evidence domain
Metabolic Health
Energy balance, glucose regulation, nutrition, and metabolic resilience.
Canonical subdomains
Questions within this domain.
Glycemic biomarkers
Lab and wearable markers used to quantify glucose and insulin dynamics.
Body composition and visceral fat
Lean mass, fat mass, waist circumference, visceral adiposity, and body recomposition.
Triglycerides and metabolic lipid pattern
TG/HDL ratio, remnant cholesterol, and insulin-resistant lipid patterns.
Fatty liver / MASLD risk
Liver fat accumulation, transaminases, insulin resistance, and metabolic liver risk.
Appetite, satiety, and GLP-1 axis
Satiety hormones, appetite regulation, weight-loss pharmacology, and rebound risk.
Fasting and time-restricted eating
Meal timing, fasting windows, metabolic switching, and safety limits.
Protein, leucine, and metabolic reserve
Protein adequacy, amino-acid signaling, muscle preservation, and satiety.
Uric acid and purine metabolism
Uric acid as marker of metabolic syndrome, gout risk, fructose, alcohol, and renal handling.
Glycation and AGEs
Protein glycation, advanced glycation end-products, cooking methods, and glucose exposure.
Nutrient timing and glucose variability
Meal composition, timing, order of eating, and CGM-based behavioral feedback.
Metabolic inflammation and adipokines
Inflammatory signaling from adipose tissue and metabolic dysfunction.
Mitochondrial-metabolic flexibility
Ability to switch between fuel sources and maintain energy metabolism.
Detox, cleanse, and metabolic marketing claims
Commercial claims around cleansing, parasite cleanses, detox teas, and metabolic resets.
Microbiome-metabolic signaling
Gut microbes, short-chain fatty acids, bile acids, appetite, and glucose regulation.
Precision nutrition and nutrigenomics
Diet response by phenotype, genotype, microbiome, and wearable data.