Sarcopenia and lean mass
Age-related loss of muscle mass and quality.
D03 · EOL evidence domain
Musculoskeletal Health & Performance
Muscle, bone, mobility, recovery, and physical performance.
Canonical subdomains
Questions within this domain.
Strength, power, and grip
Max strength, explosive power, grip strength, and functional capacity.
Mobility, balance, and fall risk
Joint range, balance, gait, stability, and fall prevention.
Bone density and fracture risk
Bone mineral density, osteoporosis risk, and fracture prevention.
Tendon, ligament, and collagen matrix
Connective tissue integrity, tendinopathy, ligament recovery, and collagen remodeling.
Resistance training protocols
Training dose, frequency, intensity, progression, and aging adaptation.
Protein, leucine, and creatine
Muscle protein synthesis, strength, lean mass, and recovery supplements.
Collagen, gelatin, vitamin C
Collagen peptides, tendon/skin/joint claims, and timing with loading.
Vitamin D, calcium, K2, magnesium
Mineral and vitamin support for bone and muscle function.
Osteoarthritis and joint function
Joint degeneration, pain, stiffness, function, and mobility.
Pain-limited function
Chronic pain as a limiter of movement, sleep, mood, and longevity behaviors.
Recovery, overtraining, and adaptation
Training stress, recovery markers, injury risk, and adaptation support.
PRP, stem cells, and exosomes
Regenerative interventions for joints, tendons, and tissue repair.
Peptides for tissue repair
BPC-157, TB-500, GHK-Cu, and injury-recovery peptide claims.
Manual therapies, acupuncture, yoga, tai chi
Complementary physical practices for pain, balance, mobility, and function.
Wearable and functional metrics
Consumer and clinical tests for strength, activity, gait, and mobility.